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Pragmatic trials are studies designed to provide information for the real-world practice of clinical. They are typically characterized by a focus on practical aspects of the research design, like the recruitment process and consent in adherence, as well as the use of commonly available equipment.
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A pragmatic trial that uses various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be able to prove their validity and also helps reduce bias in the results. Too much heterogeneity, however could cause issues with the design of the trial.
Pragmatic Play Pragmatic Play, one of the biggest players on the live casino market offers a variety of classic table games, including Blackjack and Roulette. Pragmatic Play's live studios in Romania and Malta offer an authentic gaming experience for its customers, as well as a full suite of virtual betting options. The company also offers a variety of game shows that make online gambling more exciting and interactive. Some of these shows feature a live host, while others are hosted by famous personalities from the industry.
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Legality
Pragmatic Play has earned a name for itself by providing high-quality games and a superior user experience. The software is available on mobile devices as well as in various languages. Despite its relatively young age it has already established itself as a leading casino gaming platform. Wolves is one of its latest releases that is a 5-reel slot machine with a hefty RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.
Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are usually requested by practitioners and policy makers to guide their decision-making. They can be used to determine the causality of an intervention and its results. However, they shouldn't be used to substitute for explanatory trials.
The idea of pragmatism is controversial and there are doubts about whether pragmatic trials can be used to replace explanation tests or if they should serve as a complement to them. Schwartz and Lellouch1 made a distinction between explanatory studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform policy and practice decision-making. They also proposed a framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the features of a pragmatic trial that include recruitment, design and delivery of the intervention, as well as monitoring.
The number of pragmatic trials is increasing. A recent Medline search using the terms pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary care settings.